Safety of the centrally acting wake-promoting agent modafinil in hypertensive sleep apnea patients
نویسندگان
چکیده
منابع مشابه
Modafinil: expanded options for the treatment of excessive sleepiness
10.2217/14750708.2.2.191 © 2 part of Modafinil is an oral wake-promoting agent, initially approved in December 1998 for the treatment of excessive sleepiness associated with narcolepsy. Based on the results of additional randomized, placebo-controlled studies, the indication for modafinil was expanded in January 2004 to include excessive sleepiness associated with obstructive sleep apnea/hypopn...
متن کاملSleep Apnea in Patients with Stroke and Related Risk Factors
Background and Objectives: Sleep apnea involves repetitive cycles of obstructive sleep that disrupt sleep. This complication is the most important modifiable risk factors for stroke. The aim of this study was to assess sleep apnea in patients with stroke. Material and Methods: In this cross-sectional study, 132 patients with stroke were recruited using convenience samplin...
متن کاملEffects of modafinil and amphetamine on sleep-wake cycle after sleep deprivation in cats.
AIM The effects of modafinil and amphetamine on sleep-wake cycle and cortical power spectrum were assessed in the cats before and after sleep deprivation. METHODS The sleep deprivation in the cats was used with the water tank technique. Cats were administrated with modafinil (5 mg.kg-1 p.o.) or amphetamine (1 mg.kg-1) before and after sleep deprivation. RESULTS The waking effect of 8-10 h i...
متن کاملA novel adaptive wrist actigraphy algorithm for sleep-wake assessment in sleep apnea patients.
STUDY OBJECTIVES Current actigraphic algorithms are relatively less accurate in detecting sleep and wake in sleep apnea patients than in people without sleep apnea. In the current study, we attempted to validate a novel automatic algorithm, which was developed for actigraphic studies in normal subjects and patients with obstructive sleep apnea by comparing it on an epoch-by-epoch basis to stand...
متن کاملDisharmony between wake- and respiration-promoting activities: effects of modafinil on ventilatory control in rodents
BACKGROUND Modafinil is a wake-promoting drug and has been widely used for daytime sleepiness in patients with narcolepsy and other sleep disorders. A recent case series reported that daily oral modafinil alleviated hypercapnic respiratory failure in patients with COPD. However, the precise action of modafinil on respiration such as hypercapnic and/or hypoxic ventilatory responses remains uncle...
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ژورنال
عنوان ژورنال: Journal of the American College of Cardiology
سال: 2003
ISSN: 0735-1097
DOI: 10.1016/s0735-1097(03)82455-5